The Lossen rearrangement from free hydroxamic acids
نویسندگان
چکیده
منابع مشابه
Formation of a Chiral Hydroxamic Acid with an Amidase from Rhodococcus erythropolis MP50 and Subsequent Chemical Lossen Rearrangement to a Chiral Amine.
The amidase from Rhodococcus erythropolis MP50 demonstrated, in the presence of hydroxylamine, acyltransferase activity and catalyzed the formation of hydroxamates from amides and hydroxylamine. The rates of acyltransferase activity of the purified amidase for the substrates acetamide, phenylacetamide, and 2-phenylpropionamide were higher than the corresponding rates for the hydrolysis reaction...
متن کاملTheoretical Studies on Hydroxamic Acids
Hydroxamic acids find many applications in chemistry and biology and have been the subject of many experimental investigations. Theoretical studies are not as frequent. However, the smallest homolog, formohydroxamic acid (FHA), has been studied at various levels, including high-level ab initio and density functional with large basis sets. All studies indicate that it exists as the Z-amide tauto...
متن کاملPhysiological role of the cyclic hydroxamic acids
Roots of young seedleings of barnyard grass, maize, rye and wheat secret hydroxamic acids. Their compexes with Fe/III/-ions are available sources of iron. It is possible that the cyclic hydroxamic acids play a role in the alternative mechanism of iron uptake. The hydroxamic acids secreted by barnayard grass roots have an allelopathic role by inhibiting the roots growth of rice. Acta Biol Szeged...
متن کاملFacile access to amides and hydroxamic acids directly from nitroarenes.
A new method for synthesis of amides and hydroxamic acids from nitroarenes and aldehydes is described. The MnO2 catalyzed thermal deoxygenation of nitrobenzene resulted in formation of a reactive nitroso intermediate which on reaction with aldehydes provided amides and hydroxamic acids. The thermal neat reaction in the presence of 0.01 mmol KOH predominantly led to formation of hydroxamic acid ...
متن کاملFormation of stable anhydrides from CoA transferase and hydroxamic acids.
Acetohydroxamic acid reacts with the enzyme-CoA form of succinyl-CoA:3-ketoacid coenzyme A transferase to give an inactive product with a rate constant of 860 M-1 min-1 at pH 8.1, 25 degrees C. The reaction is reversible in the presence of coenzyme A and has an equilibrium constant of 0.040. The product is an anhydride that is an analog of the intermediate that has been postulated in the normal...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2019
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c9ob00789j